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  Aurora 1400A Permeabilized Fiber System

 

Aurora 1400A Permeabilized Fiber System

 

Overview:

 The 1400A and 1410A Permeabilized Fiber Systems are designed to enhance experimental throughput and simplify complex permeabilized fiber experiments. They provide accurate measurements of fiber properties across a broad range of applications and tests. Performing a force-pCa experiment is a breeze with our automatically indexing bath plate. Pre-program calcium concentrations and activation/relaxation sequences and let the 1400A system do the rest.

               

 

 

 

Technology principle

Included is temperature controlled apparatus which includes XYZ micrometer stages with built-in mounts for our high-speed length controllers and force transducers. The bath controller features exclusive software with a programmable motion control sequencer for automated bath transfer of the fiber being studied. Also included are a high-speed length controller, precision force transducer, data acquisition hardware and our unique real-time Linux control and analysis software.

Our dedicated software includes a library of experimental protocols, simplifying the process and allowing easy measurement of both force and length. When combined with our optional HVSL/VSL sarcomere length measurement system the researcher can control and measure length, force, and sarcomere length. These advanced features allow researchers to completely characterize permeabilized fibers performing all of the standard tests including force-pCa, kTr, length-tension, force-velocity and stiffness.

The Aurora Scientific permeabilized fiber test system is manufactured using corrosion resistant materials and can easily mount on an inverted microscope for basic observation or more sophisticated imaging.

Description: C:\Users\user\Dropbox\ASI - 1300 system\ASI__1300_Software_02.jpg

 

1400A specifications

315C-I/322C: High-Speed Length Controller

403A: Force Transducer

600A: Real-Time Muscle Data Acquisition and Analysis System

802D: Permeabilized Fiber Apparatus – Microscope Mountable

 

Paper list

Stoehr, Andrea, et al. “Automated analysis of contractile force and Ca2+ transients in engineered heart tissue.” American Journal of Physiology-Heart and Circulatory Physiology 306.9 (2014): H1353-H1363.

Shimkunas, Rafael, et al. “Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone.” American Journal of Physiology-Heart and Circulatory Physiology 307.8 (2014): H1150-H1158.

Gineste, Charlotte, et al. “Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy.” PloS One 9.9 (2014): e109066.

Klaiman, Jordan M. “Cold acclimation increases cardiac myofilament function and ventricular pressure generation in trout.” The Journal of Experimental Biology 217 (2014): 4132-4140.

Bezold, Kristina L. et al. “A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin.” Journal of Biological Chemistry 288.30 (2013): 21496-21505.

Kohn, Tertius A. and Timothy D. Noakes. “Lion (Panthera leo) and caracal (Caracal caracal) type IIx single muscle fibre force and power exceed that of trained humans.” The Journal of Experimental Biology 216.6 (2013): 960-969.

Lee, Eun-Jeong, et al. “Calcium sensitivity and myofilament lattice structure in titin N2B KO mice.” Archives of Biochemistry and Biophysics 535.1 (2013): 76-83.

Choi, Seung Jun et al. “Force-Generation Capacity of Single Vastus Lateralis Muscle Fibers and Physical Function Decline With Age in African Green Vervet Monkeys.” Journal of Gerontology Series A: Biological Sciences and Medical Sciences 68.3 (2013): 258-267.

Ochala, Julien and Lars Larsson. “Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres.” Experimental Physiology 93.4 (2008): 486-495.

 


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