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  MagneTherm™ system

 

MagneTherm™ system

Overview:

      MagneTherm ™ magnetic heat treatment analysis system is a kind of high precision magnetic Nanotherics company heat test system is the system by controlling the surface functionalization of magnetic nanoparticles to produce heat for heat treatment. MagneTherm ™ magnetic heat treatment analysis system using alternating magnetic field (AMF) and magnetic nanoparticles (MNPs) as a tumor cells and other heating methods, by applying the alternating magnetic field of a certain intensity, magnetic particles under the action of alternating magnetic field can absorb electromagnetic energy into heat energy, systems and control heat confined to the tumor tissue, can lead to cell apoptosis and necrosis, so as to realize the heat treatment of the tumor and the related research. The system can also control the tissue targeting and cell specific targeting of the magnetic fluid movement of nanometer

 

    

 

Technology principle

  By controlling the nanoscale magnetic particles in tumor tissues, and then put a external alternating magnetic field, make the material because of the hysteresis, relaxation or induced eddy current and is heated, the heat transfer to material surrounding tumor tissue, the tumor tissue temperature more than 42 and lead to cell apoptosis and necrosis, so as to realize the treatment of the tumor.

Heat MagneTherm ™ magnetic testing system of killing tumor cells main principles :

(1) high temperature changes the mitochondrial membrane fluidity of tumor cells and destroys the enzyme system required for DNA synthesis, leading to tumor cell death; The pH value of tumor tissue decreased after heat treatment, which increased the killing effect on tumor cells.

(2) irregular blood vessels and low heat dissipation capacity of tumor increase the selectivity of high temperature action on tumor tissues and increase the NK size the activity of cells, NK cells have the activity of killing tumor cells without the activation of tumor antigen the tumor cell receptors in the surface bind to tumor cells and release lysosomes.

 

(3) promote the maturation of dendritic cells (DC). Immature dendritic cells are precursors of mature dendritic cells strong antigen uptake capacity. But due to its low surface expression of MHC , and stimulating molecules, and thus cannot effectively the ability to stimulate T cells was reduced by presenting antigens to T lymphocytes. Mature dendritic cells can significantly stimulate the initial dendritic cells are added, so dendritic cells are the initiators of the body's immune response.

(4) magnetic heat treatment can increase the tumor cell surface MHC expression, thus activating the T cell mediated antitumor immunity immune response.

 

Applications

ü  animal tumor cure

ü  tumor cell research

ü  magnetic nanoparticles synthesis

ü  pharmacy

ü  heat shock protein

ü  drug release

ü  pharmacology & biochemist

 

Magnetherm specification

 1. Including dc power supply system, function signal generator, oscilloscope

2 Dc power supply system24cm (W) x 32cm (D) x 13cm (H)

3. function signal generator22cm (W) x 29cm (D) x 10cm (H)

4. oscilloscope35cm (W) x 44cm (D) x 17cm (H)

5. 17 turns9 turns heating coils

6. Temperature probe (T thermocouple)

7. Dc stabilized voltage source

8. Test tube sample of polystyrene

9. Pipeline and gasket, cooling water connection pipe, connection cable

 

Paper list

1.     Pankhurst, Q.A., Connolly, J., Jones, S.K. and Dobson, J.J., 2003. Applications of magnetic nanoparticles in biomedicine. Journal of physics D: Applied physics, 36(13), p.R167. doi: 10.1088/0022-3727/36/13/201 (IF: 2.772)

2.      Krishnan, K.M., 2010. Biomedical nanomagnetics: a spin through possibilities in imaging,diagnostics, and therapy. Magnetics, IEEE Transactions on, 46(7), pp.2523-2558. doi:10.1109/TMAG.2010.2046907 (IF: 1.277)

3.     Khandhar, A.P., Ferguson, R.M. and Krishnan, K.M., 2011. Monodispersed magnetite nanoparticles optimized for magnetic fluid hyperthermia: Implications in biological systems. Journal of applied physics, 109(7), p.07B310. doi: 10.1063/1.3556948 (IF: 2.101)

4.     Paolella, A., George, C., Povia, M., Zhang, Y., Krahne, R., Gich, M., Genovese, A., Falqui, A., Longobardi, M., Guardia, P. and Pellegrino, T., 2011. Charge transport and electrochemical properties of colloidal greigite (Fe3S4) nanoplatelets. Chemistry of Materials, 23(16), pp.3762- 3768. doi: 10.1021/cm201531h (IF: 9.407)

5.     Khandhar, A.P., Ferguson, R.M., Simon, J.A. and Krishnan, K.M., 2012. Enhancing cancer therapeutics using size-optimized magnetic fluid hyperthermia. Journal of applied physics, 111(7), p.07B306. doi: 10.1063/1.3671427. (IF: 2.101)

6.     Khandhar, A.P., Ferguson, R.M., Simon, J.A. and Krishnan, K.M., 2012. Tailored magnetic nanoparticles for optimizing magnetic fluid hyperthermia. Journal of Biomedical Materials Research Part A, 100(3), pp.728-737. doi: 10.1002/jbm.a.34011 (IF: 3.263)

7.     Roca, A.G., Wiese, B., Timmis, J., Vallejo-Fernandez, G. and O'Grady, K., 2012. Effect of frequency and field amplitude in magnetic hyperthermia. Magnetics, IEEE Transactions on, 48(11), pp.4054- 4057. doi: 10.1109/TMAG.2012.2201459 (IF: 1.277)

8.     Armijo, L.M., Brandt, Y.I., Mathew, D., Yadav, S., Maestas, S., Rivera, A.C., Cook, N.C., Withers, N.J., Smolyakov, G.A., Adolphi, N.L., Monson, T.C., Huber, D.L., Smyth, H.D. and Osiski M., 2012. Iron oxide nanocrystals for magnetic hyperthermia applications. Nanomaterials, 2(2), pp.134-146. doi:10.3390/nano2020134 (IF: 2.690)

 

Some domestic user list:

 

 


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